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tumour lysis syndrome 

Here you will find basic and more advanced resources about tumour lysis syndrome. If you want to test your knowledge first, take the quiz. ​

The basics

Videos

Tumour lysis syndrome describes excessive cancer cell lysis occurring spontaneously or following cytotoxic treatment. It most commonly occurs with bulky chemosensitive malignancies like lymphomas and leukemias. Laboratory tumour lysis syndrome is defined by at least two of hypocalcaemia, hyperkalaemia, hyperuricaemia and hyperphosphataemia, Clinical tumour lysis syndrome is two of the laboratory features plus one of: increased creatinine, cardiac arrhythmias, seizures or death. 
It is important to risk assess patients as prophylactic treatment is effective. Hydration and hypouricaemic agents (such as allopurinol and rasburicase) form the backbone of management. 
Great clinical case and explanation from Anna Pickens in only 5 minutes
LITFL
A life in the fast lane overview of tumour lysis syndrome from the perspective of working up a patient in the emergency department

Deeper dive

NEJM 2012 Review
Open access New England Journal of Medicine 2012 indepth review 
A good overview of the pathophysiology from Oncology for Medical Students youtube channel

Now take the quiz

Burkitt Lymphoma (FNA, Giemsa stain) by Ed Uthman, Creative Commons Attribution 2.0 Generic
Copyright © 2015
  • Welcome
  • Oncology Basics
    • Oncology Careers
    • Radiation Basics
    • Chemo Corner
  • Emergency cases
    • Neutropenic Sepsis >
      • Quiz
      • Notes
    • Malignant Spinal Cord Compression >
      • Quiz
      • Notes
    • Hypercalcaemia >
      • Quiz
      • Notes
    • Tumour Lysis Syndrome >
      • Quiz
      • Notes
    • Superior Vena Cava Syndrome >
      • Quiz
      • Notes
  • Hot Topics
    • Immunotherapy
    • CAR-T Therapy
    • Proton Therapy
  • FOAM Resources
  • Join the FOAM party