Here you will find basic and more advanced resources about tumour lysis syndrome. If you want to test your knowledge first, take the quiz.
The basics |
Videos |
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Tumour lysis syndrome describes excessive cancer cell lysis occurring spontaneously or following cytotoxic treatment. It most commonly occurs with bulky chemosensitive malignancies like lymphomas and leukemias. Laboratory tumour lysis syndrome is defined by at least two of hypocalcaemia, hyperkalaemia, hyperuricaemia and hyperphosphataemia, Clinical tumour lysis syndrome is two of the laboratory features plus one of: increased creatinine, cardiac arrhythmias, seizures or death.
It is important to risk assess patients as prophylactic treatment is effective. Hydration and hypouricaemic agents (such as allopurinol and rasburicase) form the backbone of management. |
Great clinical case and explanation from Anna Pickens in only 5 minutes
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A life in the fast lane overview of tumour lysis syndrome from the perspective of working up a patient in the emergency department
Deeper diveOpen access New England Journal of Medicine 2012 indepth review
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A good overview of the pathophysiology from Oncology for Medical Students youtube channel
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